Research at Radial

Backed by research.
Driven by care.

Radial clinicians don't just follow the research, they conduct it. From neuromodulation to digital psychiatry, our team actively publishes and participates in clinical trials, ensuring every patient receives care that is grounded in the best available evidence.

Featured publication

Mentalization-Based Treatment for Adolescents: The Framework for Work with Suicide and Self-Injurious Behaviors

Adolescents who self-harm or experience suicidal ideation are among the most challenging patients to engage therapeutically. This chapter presents the Mentalizing-Based Treatment framework for navigating these high-stakes clinical situations with structure, safety, and relational attunement.

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Trudie Rossouw, Owen Muir, Laurel L Williams
Adolescents who self-harm or experience suicidal ideation are among the most challenging patients to engage therapeutically. This chapter presents the Mentalizing-Based Treatment framework for navigating these high-stakes clinical situations with structure, safety, and relational attunement.
Recently in research
External Publications
June 2026

Functional Recovery After Multimodal Noninvasive Neuromodulation for Multimorbid PTSD, Bipolar Mania With Psychosis, and Psoriatic Arthritis

Muir O, Tendler A, Bermudes R
Can targeted brain stimulation help when several severe, seemingly unrelated illnesses collide in one patient? This case report describes an individual with treatment-resistant PTSD, bipolar mania with psychosis, and psoriatic arthritis who achieved meaningful functional recovery after a course of multimodal noninvasive neuromodulation. Alongside marked psychiatric improvement, the patient's inflammatory joint symptoms also eased — pointing to possible shared mind-body pathways that brain stimulation may influence. Though based on a single case, the report suggests noninvasive neuromodulation could be worth exploring for complex, multimorbid presentations that resist conventional treatment.
Clinical Trials
June 2026

Cross-Dataset Evaluation of an Automated Video-Based Model for Detecting Tardive Dyskinesia Using the Clinician's Tardive Inventory: Validation Study

Trosch R, Sterns A, Grimm B, Larsen L, Talbot B, Ma F, Ranjan R, MacMillan C, Hughes J, Friedman J, Muir O
Can AI reliably spot a movement disorder that clinicians routinely miss? This validation study found that an AI-powered video analysis model accurately detected tardive dyskinesia — a common side effect of long-term antipsychotic use — even when video recordings weren't collected under standardized conditions. The model showed strong agreement with expert clinician ratings and high diagnostic accuracy, suggesting it could support earlier, more consistent screening in real-world clinical settings.
External Publications
April 2026

Mentalization-Based Treatment for Adolescents: The Framework for Work with Suicide and Self-Injurious Behaviors

Trudie Rossouw, Owen Muir, Laurel L Williams
Adolescents who self-harm or experience suicidal ideation are among the most challenging patients to engage therapeutically. This chapter presents the Mentalizing-Based Treatment framework for navigating these high-stakes clinical situations with structure, safety, and relational attunement.

Publications

April 2026
Deep TMS
Safety and Efficacy of Deep TMS for Adolescent Depression: A Post-Marketing Surveillance Study
Yiftach Roth, Oluremi Adefolarin, Richard Bermudes, Mark Blair, Raymond Cho, Dianne Dekeyser, Raymond Garcia, Diana Ghelber, Steven Harvey, Kevin Kinback, Carlene MacMillan, Mah Mekolle, Owen Muir, Gabriel Pell, Teresa Poprawski, Alexander Rohr, Kevin Rosi, Jason Tripp, Aron Tendler, Colleen Hanlon
Adolescent depression demands safe, effective options — especially when medications fall short. This post-marketing surveillance study confirms that Deep TMS is well-tolerated and clinically effective for adolescents with treatment-resistant depression across real-world practice sites.
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Deep TMS
April 2026
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Assessing the Effectiveness of the SAINT® Neuromodulation System to Treat Major Depressive Disorder in a Real-World Setting: A Multisite, Open-Label Optimization Study
Hugh B Solvason, Roger Pottanat, Owen S Muir, Carlene MacMillan, Ian A Cook, David M Carreon, Robert Bota, Tracy Barbour, Rebecca M Allen, Katy Stimpson, Michael Feyder, TJ Ford, Nolan R Williams, Brandon S Bentzley
Real-world use of SAINT raises a critical question: does it hold up outside of controlled trials? This multisite open-label study confirms that the SAINT neuromodulation system produces meaningful antidepressant outcomes in community clinical settings.
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April 2026
Deep TMS
Resolution of Aphasia and Gait Instability in a Patient With HSV Encephalitis After dTMS Treatment: A Case Report
Amna Aslam, Owen Muir, Stephanie Sizemore, Irfan Handoo
A patient recovering from viral encephalitis loses the ability to speak and walk — then regains both after Deep TMS. This case report documents a striking recovery of aphasia and gait instability following dTMS treatment, suggesting potential neurorehabilitative applications.
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Deep TMS
April 2026
Accelerated TMS
Beyond the PHQ-9 and Into the DSM-XC: Transdiagnostic and Functional Assessment of Accelerated TMS Outcomes
Amna Aslam, Carlene MacMillan, Owen Muir
The PHQ-9 tells you a patient is depressed. But does it tell you enough? This paper examines accelerated TMS outcomes through a broader transdiagnostic lens, using DSM-5 criteria to capture functional recovery that symptom scales alone can miss.
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Accelerated TMS
April 2026
Ketamine Therapy
Mapping the Use of Ketamine in Treatment-Resistant Depression and Other Psychiatric Disorders: A Scoping Review of Practice Patterns, Efficacy, and Patient Demographic Trends
Amna M Aslam, Kenneth Shinozuka, Owen Muir, Burton J Tabaac
Ketamine has moved from operating rooms to psychiatric clinics — but how is it actually being used? This scoping review maps real-world ketamine practice patterns across treatment-resistant depression and other disorders, revealing wide variation in dosing, setting, and patient demographics.
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Ketamine Therapy
April 2026
Accelerated TMS
Saint Neuromodulation System to Treat Major Depressive Disorder in Adolescents
Ian A Cook, David M Carreon, Hugh B Solvason, Robert Bota, Tracy Barbour, Roger Pottanat, Owen S Muir, Carlene MacMillan, Rebecca M Allen, Katy H Stimpson, Michael Feyder, TJ Ford, Nolan R Williams, Brandon Bentzley
Can the SAINT neuromodulation system help adolescents with treatment-resistant depression when other options have failed? This study evaluates the accelerated iTBS protocol in teens, adding to a growing body of evidence for intensive neuromodulation in younger patients.
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Accelerated TMS
April 2026
AI / Digital Psychiatry
Detecting Tardive Dyskinesia Using Video-Based Artificial Intelligence
Anthony A Sterns, Joel W Hughes, Bradley Grimm, Loren Larsen, Fred Ma, Rakesh Ranjan, Carlene MacMillan, Bretton H Talbot, Joseph H Friedman, Owen S Muir
Tardive dyskinesia is often missed until it's severe — but what if a camera could catch it first? This study demonstrates that video-based AI can reliably detect the involuntary movements of TD, opening the door to earlier intervention and better patient monitoring.
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AI / Digital Psychiatry
April 2026
Deep TMS
Safety and efficacy of Deep TMS for adolescent depression based on large real-world data analysis
Yiftach Roth, Aron Tendler, Gaby S Pell, TeeJay Tripp, Philip Yam, Dianne DeKeyser, Mah Mekolle, Jayson Tripp, Aaron J Dahl, Owen S Muir, Carlene M MacMillan, Kevin R Rosi, Steven A Harvey, Teresa Poprawski, Kevin M Kinback, Oluremi Adefolarin, Alexander Rohr, Mark E Blair, Diana Ghelber, Raymond Y Cho, Hannah R Kelly, Raymond C Garcia, Amita Jha, Richard A Bermudes, Colleen A Hanlon
Is Deep TMS safe and effective for adolescents — a population it wasn't originally cleared for? This landmark real-world analysis of over 1,200 patients across 56 sites confirms strong response and remission rates with an adverse event profile comparable to adults.
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Deep TMS
April 2026
Mentalizing-Based Therapy
Basic Concepts in Mentalizing-Based Therapy for Adolescents With Mood Dysregulation
Laurel L Williams, Owen S Muir, Sindhu A Idicula, Carl Fleisher, Carlene M MacMillan, Robert A Dugger
How do you treat mood dysregulation in adolescents when emotions feel too big to name? This paper lays out the foundational concepts of Mentalizing-Based Therapy, a structured approach to helping teens develop self-awareness and emotional regulation.
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Mentalizing-Based Therapy
April 2026
Deep TMS
Accelerated Deep TMS for Depression: Results from a Multisite, Randomized Non-Inferiority Trial
Colleen A Hanlon, Yiftach Roth, Richard A Bermudes, Eliza Brink, Molly Davis, Dawn DeBrocco, Shelli Ellis, Lindsey Jones, Aftab Khan, Carlene MacMillan, Aswin Kumar Mudunuru, Owen Muir, Gabriel S Pell, Timothy Prestley, MS Reddy, Elyssa Sisko, Samson Seplow, Natanya Slomowitz, Ahava Stein, Daniel B Thistlewaite, Russ Voltin, Aron Tendler
Fewer visits shouldn't mean worse outcomes. This multisite non-inferiority trial found that accelerated Deep TMS — compressed into six half-day sessions — matched standard weeks-long protocols in response and remission rates, with faster time to remission.
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Deep TMS
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Personality Disorders
Narcissism
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Mentalizing-Based Therapy
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Deep TMS
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Deep TMS
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Mentalizing-Based Therapy
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Mentalizing-Based Therapy
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Deep TMS
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AI / Digital Psychiatry
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Deep TMS
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Deep TMS
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Deep TMS
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Ketamine Monitoring
PTSD
Bipolar
TMS
Movement Disorders
AI / Digital Psychiatry
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Accelerated TMS
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AI / Digital Psychiatry
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Accelerated TMS
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Accelerated TMS
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TMS
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Psychedelic Therapy
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Psychedelic Therapy
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Psychedelic Therapy
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Psychedelic Therapy
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Psychedelic Therapy
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Psychedelic Therapy
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Psychedelic Therapy
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Psychedelic Therapy
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Deep TMS
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Mentalizing-Based Therapy
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Accelerated TMS
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Accelerated TMS
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Accelerated TMS
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Deep TMS
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Deep TMS
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Accelerated TMS
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Ketamine Therapy
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Active Clinical Trials

AI / Digital Psychiatry

Cross-Dataset Evaluation of an Automated Video-Based Model for Detecting Tardive Dyskinesia Using the Clinician's Tardive Inventory: Validation Study

Can AI reliably spot a movement disorder that clinicians routinely miss? This validation study found that an AI-powered video analysis model accurately detected tardive dyskinesia — a common side effect of long-term antipsychotic use — even when video recordings weren't collected under standardized conditions. The model showed strong agreement with expert clinician ratings and high diagnostic accuracy, suggesting it could support earlier, more consistent screening in real-world clinical settings.
View
Trosch R, Sterns A, Grimm B, Larsen L, Talbot B, Ma F, Ranjan R, MacMillan C, Hughes J, Friedman J, Muir O
Can AI reliably spot a movement disorder that clinicians routinely miss? This validation study found that an AI-powered video analysis model accurately detected tardive dyskinesia — a common side effect of long-term antipsychotic use — even when video recordings weren't collected under standardized conditions. The model showed strong agreement with expert clinician ratings and high diagnostic accuracy, suggesting it could support earlier, more consistent screening in real-world clinical settings.

Recent PR

Press

Postpartum OCD: Why New Parents Experience Frightening Intrusive Thoughts

Postpartum OCD can cause terrifying intrusive thoughts, compulsive checking, and intense fear after childbirth. Learn what's happening and how to get help.
View more

Leadership

Dr. Owen Scott Muir

Co-founder & Chief Medical Officer

MD, DFAACAP

Dual board-certified child, adolescent and adult psychiatrist, and author of the award-winning Frontier Psychiatrists newsletter and podcast

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Dr. Carlene MacMillan

Co-founder & Chief Product Officer

MD, FCTMSS, DFAACAP

Dual board-certified child, adolescent, and adult psychiatrist focused on expanding access to breakthrough treatments through better technology and insurance coverage advocacy.

Read more

John Capecelatro

CEO & Co-Founder

Elliot Cohen

Executive Chairman & Co-Founder

Stephanie Fillion

VP of Engineering

Jonathan Murray

Chief Commercial Officer

Leah Connor

VP of Operations

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