Research • Advancing what works in brain medicine

Research at Radial

Backed by research.
Driven by care.

Radial clinicians don't just follow the research, they conduct it. From neuromodulation to digital psychiatry, our team actively publishes and participates in clinical trials, ensuring every patient receives care that is grounded in the best available evidence.

Research areas

Movement Disorders

Schizophrenia Spectrum Disorders

Bipolar

Personality Disorders

OCD

PTSD

Anxiety

Depression

Publications

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Patient-reported outcomes following accelerated vs. standard TMS with the H1 coil for major depression: A multisite randomized trial

Tendler A, Roth Y, Bates M, Brink E, Davis M, DeBrocco D, Ellis S, Jones L, Khan A, Luce S, McMillan C, Mudunuru AK, Muir O, Pell GS, Prestley T, Reddy MS, Rodriguez N, Seplow S, Slomowitz N, Stein A, Thistlethwaite DM, Voltin R, Williams N, Hanlon CA.

What does recovery actually feel like for patients — and does it matter how fast treatment happens? This multisite randomized trial found that accelerated TMS delivers patient-reported improvements in depression, anxiety, and quality of life comparable to standard treatment, with faster perceived relief.

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Accelerated TMS with the H1-coil for depression: A multisite, randomized non-inferiority trial

Colleen A. Hanlon, Yiftach Roth, Richard A. Bermudes, Eliza Brink, Molly Davis, Dawn DeBrocco, Shelli Ellis, Lindsey Jones, Aftab Khan ∙ Carlene MacMillan, Aswin Kumar Mudunuru, Owen Muir, Gabriel S. Pell, Timothy Prestley, M.S. Reddy, Adi Rachelson, Elyssa Sisko, Samson Seplow, Natanya Slomowitz, Ahava Stein, Daniel B. Thistlethwaite, Russ Voltin, Aron Tendler

Can depression be treated just as effectively in days instead of weeks? This multisite randomized trial shows accelerated TMS delivers comparable patient outcomes to standard treatment—while significantly reducing time to relief.

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Accelerated Deep TMS for Depression: Results from a Multisite, Randomized Non-Inferiority Trial

Colleen A Hanlon, Yiftach Roth, Richard A Bermudes, Eliza Brink, Molly Davis, Dawn DeBrocco, Shelli Ellis, Lindsey Jones, Aftab Khan, Carlene MacMillan, Aswin Kumar Mudunuru, Owen Muir, Gabriel S Pell, Timothy Prestley, MS Reddy, Elyssa Sisko, Samson Seplow, Natanya Slomowitz, Ahava Stein, Daniel B Thistlewaite, Russ Voltin, Aron Tendler

Fewer visits shouldn't mean worse outcomes. This multisite non-inferiority trial found that accelerated Deep TMS — compressed into six half-day sessions — matched standard weeks-long protocols in response and remission rates, with faster time to remission.

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Basic Concepts in Mentalizing-Based Therapy for Adolescents With Mood Dysregulation

Laurel L Williams, Owen S Muir, Sindhu A Idicula, Carl Fleisher, Carlene M MacMillan, Robert A Dugger

How do you treat mood dysregulation in adolescents when emotions feel too big to name? This paper lays out the foundational concepts of Mentalizing-Based Therapy, a structured approach to helping teens develop self-awareness and emotional regulation.

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Safety and efficacy of Deep TMS for adolescent depression based on large real-world data analysis

Yiftach Roth, Aron Tendler, Gaby S Pell, TeeJay Tripp, Philip Yam, Dianne DeKeyser, Mah Mekolle, Jayson Tripp, Aaron J Dahl, Owen S Muir, Carlene M MacMillan, Kevin R Rosi, Steven A Harvey, Teresa Poprawski, Kevin M Kinback, Oluremi Adefolarin, Alexander Rohr, Mark E Blair, Diana Ghelber, Raymond Y Cho, Hannah R Kelly, Raymond C Garcia, Amita Jha, Richard A Bermudes, Colleen A Hanlon

Is Deep TMS safe and effective for adolescents — a population it wasn't originally cleared for? This landmark real-world analysis of over 1,200 patients across 56 sites confirms strong response and remission rates with an adverse event profile comparable to adults.

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Detecting Tardive Dyskinesia Using Video-Based Artificial Intelligence

Anthony A Sterns, Joel W Hughes, Bradley Grimm, Loren Larsen, Fred Ma, Rakesh Ranjan, Carlene MacMillan, Bretton H Talbot, Joseph H Friedman, Owen S Muir

Tardive dyskinesia is often missed until it's severe — but what if a camera could catch it first? This study demonstrates that video-based AI can reliably detect the involuntary movements of TD, opening the door to earlier intervention and better patient monitoring.

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Saint Neuromodulation System to Treat Major Depressive Disorder in Adolescents

Ian A Cook, David M Carreon, Hugh B Solvason, Robert Bota, Tracy Barbour, Roger Pottanat, Owen S Muir, Carlene MacMillan, Rebecca M Allen, Katy H Stimpson, Michael Feyder, TJ Ford, Nolan R Williams, Brandon Bentzley

Can the SAINT neuromodulation system help adolescents with treatment-resistant depression when other options have failed? This study evaluates the accelerated iTBS protocol in teens, adding to a growing body of evidence for intensive neuromodulation in younger patients.

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Mapping the Use of Ketamine in Treatment-Resistant Depression and Other Psychiatric Disorders: A Scoping Review of Practice Patterns, Efficacy, and Patient Demographic Trends

Amna M Aslam, Kenneth Shinozuka, Owen Muir, Burton J Tabaac

Ketamine has moved from operating rooms to psychiatric clinics — but how is it actually being used? This scoping review maps real-world ketamine practice patterns across treatment-resistant depression and other disorders, revealing wide variation in dosing, setting, and patient demographics.

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Beyond the PHQ-9 and Into the DSM-XC: Transdiagnostic and Functional Assessment of Accelerated TMS Outcomes

Amna Aslam, Carlene MacMillan, Owen Muir

The PHQ-9 tells you a patient is depressed. But does it tell you enough? This paper examines accelerated TMS outcomes through a broader transdiagnostic lens, using DSM-5 criteria to capture functional recovery that symptom scales alone can miss.

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Resolution of Aphasia and Gait Instability in a Patient With HSV Encephalitis After dTMS Treatment: A Case Report

Amna Aslam, Owen Muir, Stephanie Sizemore, Irfan Handoo

A patient recovering from viral encephalitis loses the ability to speak and walk — then regains both after Deep TMS. This case report documents a striking recovery of aphasia and gait instability following dTMS treatment, suggesting potential neurorehabilitative applications.

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Assessing the Effectiveness of the SAINT® Neuromodulation System to Treat Major Depressive Disorder in a Real-World Setting: A Multisite, Open-Label Optimization Study

Hugh B Solvason, Roger Pottanat, Owen S Muir, Carlene MacMillan, Ian A Cook, David M Carreon, Robert Bota, Tracy Barbour, Rebecca M Allen, Katy Stimpson, Michael Feyder, TJ Ford, Nolan R Williams, Brandon S Bentzley

Real-world use of SAINT raises a critical question: does it hold up outside of controlled trials? This multisite open-label study confirms that the SAINT neuromodulation system produces meaningful antidepressant outcomes in community clinical settings.

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Safety and Efficacy of Deep TMS for Adolescent Depression: A Post-Marketing Surveillance Study

Yiftach Roth, Oluremi Adefolarin, Richard Bermudes, Mark Blair, Raymond Cho, Dianne Dekeyser, Raymond Garcia, Diana Ghelber, Steven Harvey, Kevin Kinback, Carlene MacMillan, Mah Mekolle, Owen Muir, Gabriel Pell, Teresa Poprawski, Alexander Rohr, Kevin Rosi, Jason Tripp, Aron Tendler, Colleen Hanlon

Adolescent depression demands safe, effective options — especially when medications fall short. This post-marketing surveillance study confirms that Deep TMS is well-tolerated and clinically effective for adolescents with treatment-resistant depression across real-world practice sites.

Learn more about our team